Milo, incorporated in 1823, derives its name from the Penobscot word "mile-u," meaning "where two streams meet," referencing its location at the confluence of the Piscataquis and Sebec Rivers.

In its early years, Milo served as a significant lumbering town, with sawmills and logging camps fueling its economy.

The arrival of the Bangor and Aroostook Railroad in 1894 transformed Milo into a transportation hub, connecting it to major markets and facilitating the growth of agriculture and tourism.

Milo played a vital role in the American Civil War, contributing over 200 volunteers to the Union Army, including several who rose to the rank of captain and major.

The town's historic downtown district features well-preserved Victorian architecture, including the 1892 Milo Town Hall, a testament to its prosperous past.

With a population of around 2,400, Milo's demographics reflect a mix of working-class families, retirees, and seasonal residents drawn to its scenic beauty and recreational opportunities.

The Piscataquis County Ice Festival, held annually in January, showcases ice sculptures created by local artists, attracting visitors from across the region.

Milo is home to the Holbrook Island Sanctuary, which encompasses over 2,000 acres of undeveloped forest, lakes, and wetlands, providing habitat for a diverse range of plant and animal species.

The Pleasant River Wildlife Management Area, located partially within Milo, offers excellent hunting, fishing, and wildlife viewing opportunities.

The town's economy is primarily driven by tourism, retail, and healthcare services, with major employers including Katahdin Woods and Wings, a national leader in outdoor recreation.

Milo High School has a long-standing tradition of academic excellence, consistently ranking among the top schools in Maine.

The town is home to the Milo Historical Society, which preserves and showcases the rich history of the community through exhibits and events.

Milo is part of Maine's "Moose Alley," a region known for its high moose population, offering visitors frequent opportunities to spot these majestic animals in their natural habitat.

The Katahdin Woods and Waters National Monument, located adjacent to Milo, encompasses vast forests, mountains, and lakes, providing endless opportunities for adventure and exploration.

Milo's central location within Maine makes it an ideal base for day trips to popular destinations such as Acadia National Park, Baxter State Park, and the historic city of Bangor.