Acquasanta Terme's history stretches back to Roman times, evidenced by the discovery of ancient thermal baths and artifacts, suggesting its therapeutic waters were already valued centuries ago.

Geographically, Acquasanta Terme is located in the mountainous Ascoli Piceno province of Marche, nestled in the Sibilline Mountains National Park, providing a landscape characterized by forests, rivers, and diverse flora and fauna.

The town's name, meaning "Holy Water Baths," directly reflects the significance of its naturally occurring thermal springs, rich in sulfur and other minerals, which have long been central to its identity.

Demographically, Acquasanta Terme has experienced a gradual population decline in recent decades, common in many rural Italian communities, with the current population hovering around 2,500 residents.

Economically, the thermal baths and related tourism activities form the backbone of Acquasanta Terme's economy, attracting visitors seeking wellness treatments and relaxation in the natural surroundings.

The area's economy also benefits from agriculture, focusing on the production of traditional Marche region products like olive oil, wine, and locally grown grains.

Culturally, Acquasanta Terme maintains strong regional traditions, celebrated through local festivals and events, often centered on seasonal harvests and religious holidays.

The Church of Santa Maria delle Grazie, located in the center of Acquasanta Terme, is a significant landmark, showcasing local religious art and architecture, reflecting the town's deep-rooted faith.

The medieval Rocca di Acquasanta Terme, a strategically positioned fortress, offers panoramic views of the surrounding valley and stands as a testament to the town's past as a defensive stronghold.

The Sibilline Mountains National Park, encompassing Acquasanta Terme, is known for its rich biodiversity and hiking trails, promoting eco-tourism and outdoor activities in the region.

Acquasanta Terme played a role in the Italian Resistance during World War II, offering refuge to partisans and facing Nazi occupation, leaving a lasting impact on its local historical narrative.

While not a UNESCO site directly, Acquasanta Terme benefits from its proximity to areas within the Sibilline Mountains, which are under consideration for UNESCO recognition due to their exceptional natural and cultural values.

The local cuisine of Acquasanta Terme features hearty dishes based on regional ingredients, including pasta, meats, and truffles, reflecting the agricultural traditions of the Marche region.

Population growth trends in Acquasanta Terme reveal an aging demographic, prompting local initiatives to attract younger residents and revitalize the community.

The thermal waters of Acquasanta Terme are known for their therapeutic properties, specifically beneficial for treating respiratory and skin ailments, contributing to its reputation as a health and wellness destination.